Real‐world performance of the MiniMed 780G advanced hybrid closed loop system in Latin America: Substantial improvement in glycaemic control with each technology iteration of the MiniMed automated insulin delivery system
Authors' conclusion
Real-world Latin American MM780G users on average showed good glucose control, achieving international targets. Glycaemic control increased with every technology iteration of the MM system, providing more automation each time.
Study context
- Population
- MM780G system users from Argentina, Brazil, Colombia and Chile; CareLink data August 2020 to September 2022geographical analysis
- Participants
- 1,025 users
- Exposure
- MM780G vs prior MM640G or MM670G in the same individuals
- MM780Gn = 1,025
- MM640Gn = 381reference
- MM670Gn = 78reference
- Outcome
- CGM metrics in MM780G users (geographical analysis)
- Follow-up
- Mean 136 (SD 135) days
Methodological detailsCareLink data, multinational
- CareLink data
- Multinational
Main finding
As reported in the abstract
- Time in advanced hybrid closed loop, mean (SD)
- 91.5 (14.3)%
- Glucose management indicator (GMI), mean (SD)
- 6.7 (0.3)%
- TIR 70–180 mg/dl, mean (SD)
- 76.5 (9.0)%
- TBR <70 mg/dl, mean (SD)
- 2.7 (2.1)%
- Users reaching GMI <7%
- 80.8%
- Users reaching TIR >70%
- 78.1%
- Users reaching TBR <4%
- 80.1%
Observational data: associations, not effects.
Further findings
| Outcome | MM780G | MM640G | Estimate | P value |
|---|---|---|---|---|
| GMI, transition MM640G to MM780GMM780G vs MM640G · lower with MM780G | 6.7% | 7.1% | decrease 0.4 % | P < 0.0001 |
| TIR, transition MM640G to MM780GMM780G vs MM640G | 76.6% | 65.9% | increase 10.7 % | P < 0.0001 |
| Insulin delivered automatically, transition MM640G to MM780GMM780G vs MM640G · increased with MM780G | 57.7% | 47.5% | P < 0.0001 |
- GMI, transition MM640G to MM780G: N = 381
- TIR, transition MM640G to MM780G: N = 381
TIR, transition MM640G to MM780G
- TBR remained unchanged
Transition MM670G to MM780G
- Similar but less pronounced pattern
- N = 78
Original publication
Real‐world performance of the MiniMed 780G advanced hybrid closed loop system in Latin America: Substantial improvement in glycaemic control with each technology iteration of the MiniMed automated insulin delivery system. Diabetes Obes Metab. Published 13 March 2023. doi:10.
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