Diabetes technology

Early Real-World Performance of the MiniMed™ 780G Advanced Hybrid Closed-Loop System and Recommended Settings Use in the United States

Diabetes Technol TherPublished Retrospective real-world data analysis

Authors' conclusion

Early real-world MM780G use in the United States demonstrated a high percentage of time in range with low time above and below range. These outcomes are similar to those observed for real-world MM780G use in other countries.

Study context

Population
Individuals with T1D using the MM780G with Guardian 4 sensor in the US, CareLink data uploaded from launch to August 22, 2023
Exposure
Overall MM780G users vs those using recommended settings; MM770G users before vs after upgrade to MM780G
  • Overalln = 7,499reference
  • MM770Gn = 3,851
Outcome
24-h CGM metrics
Methodological detailsaggregated CareLink personal data
  • Aggregated CareLink personal data

Main finding

As reported in the abstract

GroupValue%TITR (70-140 mg/dL)
Recommended settingsmean 81.4%56.4%

Recommended settings

Valuemean 81.4%
%TITR (70-140 mg/dL)56.4%
Recommended settings use
22% of all users

Observational data: associations, not effects.

Further findings

MM770G to MM780G upgrade: %TIR, %TITR, %TAR

%TIR increased (MM770G to MM780G)
73.2% to 78.3%
%TITR increased
45.8% to 52.6%
%TAR reduced
25.1% to 20.2%
  • P < 0.001, for all three

Closed-loop (CL) exits/week

CL exits/week averaged, all MM780G users
<1

Original publication

Early Real-World Performance of the MiniMed™ 780G Advanced Hybrid Closed-Loop System and Recommended Settings Use in the United States. Diabetes Technol Ther. Published 5 February 2024. doi:10.1089/dia.2023.0453

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