Rapid gastric emptying rate in postbariatric hypoglycemia and effect of glucagon-like peptide-1 receptor agonist on postprandial hypoglycemia
Authors' conclusion
Following RYGB, individuals with PBH exhibit faster gastric emptying than unaffected SCs. GLP-1RA therapy effectively slows gastric emptying in RYGB and SG but does not prevent hypoglycemia.
Study context
- Population
- Patients after RYGB or sleeve gastrectomy (SG), with and without postbariatric hypoglycemia (PBH)
- Exposure
- PBH vs SCs; GLP-1RA vs no GLP-1RA in PBH
- PBHn = 17
- SCsn = 10reference
- Outcome
- 1-h residual volume during solid-meal scintigraphy and glucose nadir during mixed-meal tolerance testing (MMTT)
Methodological detailscross-sectional comparison
- Cross-sectional comparison
Main finding
As reported in the abstract
PBH vs SCs: P = 0.031 · GLP-1RA vs No GLP-1RA: P = 0.038 · GLP-1RA vs No GLP-1RA: P = 0.95
Observational data: associations, not effects.
Further findings
| Outcome | GLP-1RA | No GLP-1RA | P value |
|---|---|---|---|
| Time of glucose nadirGLP-1RA vs No GLP-1RA | 116 ± 36 minutes | 112 ± 22 minutes | P = 0.71 |
| Fasting glucoseGLP-1RA vs No GLP-1RA · significantly lower with GLP-1RA | 75 ± 7 | 79 ± 5 | P = 0.031 |
| Peak glucoseGLP-1RA vs No GLP-1RA · significantly higher with GLP-1RA | 176 ± 52 | 158 ± 52 | P = 0.004 |
Hypoglycemia on continuous glucose monitoring (CGM)
- CGM monitoring showed no reduction in hypoglycemia with GLP-1RA
Original publication
Rapid gastric emptying rate in postbariatric hypoglycemia and effect of glucagon-like peptide-1 receptor agonist on postprandial hypoglycemia. J Clin Endocrinol Metab. Published 24 September 2026. doi:10.
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