Radiofrequency Ablation for Solitary Autonomously Functioning Thyroid Nodules: Multicenter Study from Latin America
Authors' conclusion
The results of this multicenter study suggest that RFA is a promising treatment option for patients with solitary AFTN, regardless of their baseline characteristics, including volume, age, or composition. The clinical success of the intervention may be related to the VRR at 6 months.
Study context
- Population
- Patients with a solitary, histologically benign autonomously functioning thyroid nodule (AFTN), various countries across Latin America
- Participants
- 81 patients
- Outcome
- Resolution of hyperthyroidism
Methodological detailsobservational, multicenter
- Observational
- Multicenter
Main finding
As reported in the abstract
Rate of resolution of hyperthyroidism after radiofrequency ablation (RFA)
93.8%
76/81
Observational data: associations, not effects.
Further findings
Volume reduction ratio (VRR) · 1, 3, 6 and 12 months
- Median VRR at 1 month
- −50%
- Median VRR at 3 months
- −74.9%
- Median VRR at 6 months
- −78.4%
- Median VRR at 12 months
- −90.2%
TSH normalization · 1 and 3 months
- Normalized TSH within 1 month
- 58.02% (47/81)
- Additional normalization by 3 months
- 33.3% (27/81)
Baseline volume and clinical success
- Baseline volume ≥10, 20 or 30 mL did not affect achievement of clinical success
Predictors of resolution of hyperthyroidism (bivariate analysis) · 6 months
- VRR ≥50% at 6 months associated with resolution of hyperthyroidism
Safety
- Overall complications
- 6.2% (5/81)
- Major complication (transient Horner syndrome)
- 1.2% (1/81)
- Transient dysphonia
- 3.7% (3/81)
- Hypothyroidism requiring low-dose LT4 replacement
- 1.2% (1/81)
Original publication
Radiofrequency Ablation for Solitary Autonomously Functioning Thyroid Nodules: Multicenter Study from Latin America. Thyroid. Published 19 December 2024. doi:10.
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