QCT-based geometric, densitometric, and biomechanical properties of the aging human thoracolumbar spine
Authors' conclusion
Collectively, these findings delineate spatial and demographic patterns in vertebral strength degeneration and provide normative QCT-based reference data for biomechanical modeling.
Study context
- Population
- Radiologically healthy post-mortem spines; 9298 intact vertebral bodies T1–L59,298 vertebral bodies
- Participants
- 629 participants
- Exposure
- Female vs Male
- Femalen = 194
- Malen = 435
- Outcome
- Geometric, densitometric and biomechanical vertebral properties by age, sex, BMI and spinal level
Methodological detailspost-mortem QCT, homogenized finite element (hFE) analysis, mixed linear regression model
- Post-mortem QCT
- Homogenized finite element (hFE) analysis
- Mixed linear regression model
Main finding
As reported in the abstract
Power-law relationship between BMD and yield strength, generalized across all vertebral levels (R2)
0.91
Observational data: associations, not effects.
Original publication
QCT-based geometric, densitometric, and biomechanical properties of the aging human thoracolumbar spine. J Bone Miner Res. Published 16 January 2026. doi:10.
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