Pubertal, Auxological, and Adult Height Outcomes in Children Treated for Adrenocortical Tumors: Half a Century Experience
Authors' conclusion
Most patients treated for ACT during childhood attained AH within the TH despite presenting with advanced skeletal maturation at diagnosis. Development of CPP was not infrequent.
Study context
- Population
- Children treated for adrenocortical tumors (ACTs), followed up at a single pediatric endocrinology service in Brazil, 1966–202147 girls
- Participants
- 63 children
- Outcome
- Adult height (AH-SDS) vs target height (TH-SDS)
- Follow-up
- Adult height
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Difference between AH-SDS and TH-SDS not significant
- p = 0.3
Observational data: associations, not effects.
Further findings
Status at diagnosis and during follow-up · diagnosis to 7 years after resection
- At diagnosis median bone age (BA) more advanced than chronological age (CA), height SDS greater than TH-SDS, PAH-SDS lower than TH-SDS
- BA–CA difference decreased gradually; PAH-SDS moved closer to TH-SDS 7 years after resection
Age at puberty onset
Years
- Median CA at puberty onset, girls
- 9.3 (8.3-11.3)
- Median CA at puberty onset, boys
- 9.9 (9.2-13.6)
Central precocious puberty (CPP)
- Patients developing CPP
- 9 (6 girls)
- CPP influenced by CA >4 years at diagnosis
Original publication
Pubertal, Auxological, and Adult Height Outcomes in Children Treated for Adrenocortical Tumors: Half a Century Experience. Horm Res Paediatr. Published 22 August 2024. doi:10.
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