Psychotropic Medication Use in Children and Adolescents With Type 1 Diabetes
Authors' conclusion
This cohort study found an increasing trend in psychotropic medication dispensation among children and adolescents with T1D from 2006 to 2019, persistently higher than those without T1D. These findings call for further in-depth investigations into the benefits and risks of psychotropic medications within this population and highlight the importance of integrating pediatric diabetes care and mental health care for early detection of psychological needs and careful monitoring of medication use.
Study context
- Population
- Children and adolescents residing in Sweden, 2006–2019, followed up until December 31, 2019, 18th birthday, emigration or death; T1D median (IQR) age at diagnosis 11.1 (7.6–14.7) years13,200 with T1D
- Participants
- 3,723,745 children
- Exposure
- Children and adolescents with T1D vs peers without T1D
- T1Dn = 13,200
- Outcome
- Trends and patterns of psychotropic medication dispensation (antipsychotics, antidepressants, anxiolytics, hypnotics, mood stabilizers, ADHD medications), psychotropic medication initiation, and history of neurodevelopmental and psychiatric diagnosis
- Follow-up
- 2006–2019
Methodological detailsmultiple Swedish registers, Data analyses November 1, 2022, to April 30, 2023
- Multiple Swedish registers
- Data analyses November 1, 2022, to April 30, 2023
Main finding
As reported in the abstract
Children with T1D: dispensation 2006 → 2019
0.85% (95% CI, 0.65%-1.10%) to 3.84% (3.11%-4.69%)
Adolescents with T1D: dispensation 2006 → 2019
2.72% (95% CI, 2.15%-3.39%) to 13.54% (95% CI, 12.88%-14.23%)
Observational data: associations, not effects.
Further findings
Most commonly dispensed medications
- Hypnotics, ADHD medications, anxiolytics and SSRIs most common; all increasing
Prescription source and treatment duration in T1D
- Treatments lasting >12 months
- up to 50.1%
- Psychiatric care was the primary prescription source
Medication initiation after diabetes onset
- Higher cumulative incidence and HRs of initiation in T1D vs same-age, same-sex counterparts
Original publication
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