Proteomic associations with fluctuation and long‐term changes in BMI : A 40‐year follow‐up study
Authors' conclusion
This study highlights significant associations between plasma proteins and long-term BMI changes and fluctuations, with no evidence of PRSBMI-protein interactions influencing BMI trends. These findings underscore the substantial role of environmental factors in shaping proteome-BMI associations over adulthood.
Study context
- Population
- Finnish adult twins born before 1958 from the Older Finnish Twin Cohort, with BMI data at five time points (1975, 1981, 1990, 2011 and 2012–2014)117 men
- Participants
- 304 twins
- Outcome
- Associations of long-term BMI changes and fluctuation with 1231 plasma proteins related to cardiometabolic and inflammatory functions
- Follow-up
- 40 years
Methodological details40-year follow-up, within-pair analyses of monozygotic twins
- 40-year follow-up
- Within-pair analyses of monozygotic twins
Main finding
As reported in the abstract
Proteins associated with changes in BMI over 40 years
135
Proteins linked to fluctuation in BMI
17
Associations remaining significant in within-twin pair analyses (10 with BMI changes, 2 with fluctuation)
12
Observational data: associations, not effects.
Further findings
Polygenic risk scores for BMI (PRSBMI) and BMI trends
- PRSBMI associated with BMI changes but not with fluctuation
- Single interaction between antigen CD72 protein and baseline BMI observed
Original publication
Proteomic associations with fluctuation and long‐term changes in BMI : A 40‐year follow‐up study. Diabetes Obes Metab. Published 8 May 2025. doi:10.
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