Polygenic risk of obesity and BMI trajectories over 36 years: A longitudinal study of adult Finnish twins
Authors' conclusion
Categorizing BMI as below, within, or above polygenic risk score-predicted BMI helps identifying individuals who have been resistant or susceptible to weight gain. This may provide new insights into determinants and consequences of obesity.
Study context
- Population
- Finnish adult like-sexed twin pairs (34% monozygotic) examined at age ≈30 years in 1975, followed up in 1981, 1990 and 2011
- Participants
- 3,227 twin pairs
- Exposure
- Observed BMI below, within or above polygenic risk score-predicted BMI in 1975
- Outcome
- BMI trajectories by deviation of observed BMI from genetically predicted BMI
- Follow-up
- 36 years
Methodological detailslike-sexed twin pairs, 36-year follow-up, polygenic risk score of 996,919 SNPs
- Like-sexed twin pairs
- 36-year follow-up
- Polygenic risk score of 996,919 SNPs
Main finding
As reported in the abstract
BMI trajectories · by 2011
Mean BMI increase
4.5
95% CI 4.3–4.8
Observational data: associations, not effects.
Further findings
Twin pairs with large intrapair BMI differences (ΔBMI ≥ 3 kg/m²) · 1975
- Co-twin with higher BMI deviated above predicted BMI
- ≈2/3
- Co-twin with lower BMI deviated below prediction
- ≈1/3
- Monozygotic and dizygotic pairs
Original publication
Polygenic risk of obesity and BMI trajectories over 36 years: A longitudinal study of adult Finnish twins. Obesity (Silver Spring). Published 21 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →