Proteome organ aging and cardiometabolic risk in a population at risk for heart failure
Authors' conclusion
Proteome-derived organ aging correlates with HF severity, with possible sex-related patterns. Diabetes and higher TyG-BMI are associated with faster organ aging, which may reflect shared aging mechanisms between metabolic dysfunction and HF.
Study context
- Population
- Participants from the HELPFul cohort at risk for heart failure (HF); mean age 63 ± 9 years, 65% women; HF stage A (35%), B (29%), C/D (36%)HELPFul cohort
- Participants
- 556 participants
- Outcome
- Sex-related association between OAA of heart, artery and kidneys and HF severity
Main finding
As reported in the abstract
Association of OAA with advanced HF (Stage C/D)
Heart OAA and advanced HF (Stage C/D), women: OR
1.12 (1.03 to 1.23) (95% CI)
Heart OAA and advanced HF (Stage C/D), men: OR
1.18 (1.05 to 1.32) (95% CI)
Artery OAA and HF, women only: OR
1.10 (1.01 to 1.18) (95% CI)
Observational data: associations, not effects.
Further findings
Heart OAA and echocardiographic parameters
- Heart OAA correlated with impaired cardiac structure and function, particularly reduced ejection fraction in men and increased left ventricular mass index in both sexes
Cardiometabolic risk factors of organ aging
- Triglyceride-glucose body mass index (TyG-BMI) and advanced kidney OAA, women only: z-scored OR
- 1.88 (1.45 to 2.45) (95% CI)
- Diabetes was the most relevant factor of artery and kidney OAA
Original publication
Proteome organ aging and cardiometabolic risk in a population at risk for heart failure. Cardiovasc Diabetol. Published 12 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →