Progression of Diabetic Retinopathy After Initiation of Automated Insulin Delivery System in Adults With Type 1 Diabetes
Authors' conclusion
Higher baseline HbA1c with LDL-C >100 mg/dL may be associated with DR worsening after initiation of AID systems in T1D.
Study context
- Population
- Adults with T1D initiating automated insulin delivery (AID) systems; mean age 42 years, 57% female, T1D duration 26 years, mean baseline HbA1c 7.6% (60 mmol/mol)
- Participants
- 152 adults
- Outcome
- DR worsening: increase in Early Treatment of Diabetic Retinopathy Study (ETDRS) scores or qualitative retinal exam
- Follow-up
- Up to 2.7 years after AID initiation
Main finding
As reported in the abstract
DR worsening after AID initiation · up to 2.7 years
Adults with T1D
28%
42 events
Observational data: associations, not effects.
Further findings
| Outcome | DR worsening | No-DR worsening | P value |
|---|---|---|---|
| Decline of HbA1c with AID initiationNot significant | −0.38 ± 1.2 % | −0.47 ± 0.9 % | P = 0.6 |
Risk factors for diabetic retinopathy (DR) worsening (adjusted for age, diabetes duration and sex)
- Baseline HbA1c, OR
- 2.1 [1.34-3.04]
- Low-density lipoprotein cholesterol (LDL-C) >100 mg/dL with HbA1c >8%, OR
- 3.33 [1.12-9.91]
Original publication
Progression of Diabetic Retinopathy After Initiation of Automated Insulin Delivery System in Adults With Type 1 Diabetes. J Diabetes Sci Technol. Published 14 February 2025. doi:10.
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