Prognostic value of triglyceride-glucose index combined with stress hyperglycemia ratio for all-cause mortality in critically ill patients with stroke
Authors' conclusion
The combination of high TyG (≥ 8.72) and elevated SHR (≥ 1.18) is significantly associated with increased short- and long-term mortality in critically ill patients with stroke. Integrated metabolic monitoring and early intervention targeting at these biomarkers may improve their prognosis.
Study context
- Population
- Critically ill patients with stroke requiring intensive care unit (ICU) admission, MIMIC-IV; median age 72.63 years (IQR 61.27–82.69), 51.33% male8 groups
- Participants
- 2,998 patients
- Exposure
- Combined triglyceride-glucose (TyG) index and stress hyperglycemia ratio (SHR) categories
- Outcome
- 30-day and 365-day all-cause mortality
- Follow-up
- 30 days and 365 days
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
All-cause mortality (30-day and 365-day)
TyG ≥ 8.72 and SHR ≥ 1.18 vs TyG < 8.72 and SHR < 0.86Hazard ratio (95% CI)
30-day
2.481(1.767–3.485)
365-day
1.954(1.532–2.493)
Observational data: associations, not effects.
Secondary outcomes
Restricted cubic splines (RCS): TyG index, SHR and mortality · all time points
- Linear positive correlations (all P for non-linearity > 0.05)
Subgroup analyses · 30 days and 365 days
- Consistent associations of combined TyG and SHR with all-cause mortality
Mediation by highest SHR of high TyG–mortality association
- 30-day mediation proportion
- 48.82%, P = 0.024
- 365-day mediation proportion
- 22.93%, P = 0.004
Original publication
Prognostic value of triglyceride-glucose index combined with stress hyperglycemia ratio for all-cause mortality in critically ill patients with stroke. Cardiovasc Diabetol. Published 18 August 2025. doi:10.
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