Prognostic value of triglyceride glucose index in population at high cardiovascular disease risk
Authors' conclusion
The high TyG index was associated with an increased risk of all-cause death and cardiovascular death in people at high risk of CVD. This finding demonstrates the value of the TyG index in the primary prevention of CVD.
Study context
- Population
- Adults aged 35–75 years at high cardiovascular disease (CVD) risk visiting selected health centers and community service centers, 2017–2021; mean age 57.9 ± 9.6 years, 40.7% male, mean triglyceride glucose (TyG) index 8.9 ± 0.6
- Participants
- 35,455 adults
- Exposure
- TyG index ≥ 9.83 vs < 9.83
- Outcome
- All-cause death and cardiovascular death
- Follow-up
- Median 3.4 years
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
TyG index ≥ 9.83 vs TyG index < 9.83Hazard ratio (95% CI)P value
All-cause death; multivariate Cox model
1.86(1.37–2.51)
P < 0.001Cardiovascular death; multivariate Cox model
2.41(1.47–3.96)
P = 0.001- All-cause deaths (overall)
- 551
- Cardiovascular deaths (overall)
- 180
Observational data: associations, not effects.
Further findings
- No interaction between TyG index and variables in all subgroup analyses
Original publication
Prognostic value of triglyceride glucose index in population at high cardiovascular disease risk. Cardiovasc Diabetol. Published 3 August 2023. doi:10.
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