Prognostic significance of triglyceride-glucose index in acute coronary syndrome patients without standard modifiable cardiovascular risk factors
Authors' conclusion
The TyG index is correlated with poor prognosis in patients with ACS without SMuRFs, suggesting that it may be an independent predictive factor of adverse events among these individuals.
Study context
- Population
- Patients with acute coronary syndrome (ACS) without SMuRFs who underwent coronary angiography, Beijing Anzhen Hospital, May 2018–December 2020; mean age 59.55 ± 10.98 years
- Participants
- 1,140 patients
- Exposure
- Higher vs lower TyG index
- Outcome
- MACCE: all-cause mortality, non-fatal MI, non-fatal ischemic stroke and ischemia-driven revascularization
- Follow-up
- Median 48.3 months
Methodological detailsconsecutive patients, single-centre
- Consecutive patients
- Single-centre
Main finding
As reported in the abstract
MACCE
Estimate (95% CI)P value
Highest TyG index
HR per 1 SD increase in TyG index (continuous) 1.245(1.030–1.504)
P < 0.05Highest TyG index
HR (categorical) 1.693(1.051–2.727)
P < 0.05- Major adverse cardiac and cerebrovascular events (MACCE) events
- 220 (19.3%)
- Mean TyG index
- 8.67 ± 0.53
Observational data: associations, not effects.
Further findings
Ischemia-driven revascularization
| Estimate | P value | ||
|---|---|---|---|
| Highest TyG indexFully adjusted model | HR per 1 SD increase in TyG index (continuous) 1.303 (95% CI 1.026–1.653) | P < 0.05 | |
| Highest TyG indexFully adjusted model | HR (categorical) 1.855 (95% CI 0.998–3.449) | P = 0.051 | |
| 0.20.5125Ratio (log scale) |
Subgroups
- TyG index associated with poor prognosis among the subgroup
Original publication
Prognostic significance of triglyceride-glucose index in acute coronary syndrome patients without standard modifiable cardiovascular risk factors. Cardiovasc Diabetol. Published 23 July 2024. doi:10.
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