Prognostic indicators in medication-related osteonecrosis of the jaw: A systematic review and meta-analysis
Authors' conclusion
Results of our meta-analysis helped identify prognostic indicators of MRONJ and will assist in decision-making in the clinical setting.
Study context
- Population
- Patients undergoing treatment for medication-related osteonecrosis of the jaw (MRONJ)33 studies
- Outcome
- Prognostic factors for MRONJ treatment outcome
Methodological details33 studies included of 1,388 screened citations, Prognostic factors grouped into five categories: medication-related, underlying conditions, lesion-related, serum markers, treatment modalities
- 33 studies included of 1,388 screened citations
- Prognostic factors grouped into five categories: medication-related, underlying conditions, lesion-related, serum markers, treatment modalities
Pooled result
As reported in the abstract
- Discontinuation of antiresorptive therapy significantly associated with better treatment outcomes
- Malignancy, especially multiple myeloma, associated with worse treatment outcomes
- Better treatment outcome for maxillary lesions and lesions with sequestrum formation
- Advanced-stage lesions and lesions with periosteal reaction had poor treatment outcomes
- Surgical therapy associated with a better chance of healing
Original publication
Prognostic indicators in medication-related osteonecrosis of the jaw: A systematic review and meta-analysis. Osteoporos Int. Published 24 March 2025. doi:10.
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