Prognostic importance of glycemic variability on left ventricular reverse remodeling after the first episode of ST-segment elevation myocardial infarction
Authors' conclusion
Low GV, determined using a CGMS, was significantly associated with LVRR, which might lead to a good prognosis. Further studies are needed to validate the importance of GV in LVRR in patients with STEMI.
Study context
- Population
- Patients with first STEMI who underwent reperfusion therapy within 12 h of onset
- Participants
- 201 consecutive patients
- Exposure
- Glycemic variability and left ventricular reverse remodeling (LVRR); LVRR vs no LVRR for major adverse cardiovascular events (MACE)
- LVRRn = 57
- Outcome
- LVRR: absolute decrease in LV end-systolic volume index >10% on cardiac magnetic resonance imaging (CMRI)
- Follow-up
- 1 week to 7 months after admission
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
MAGE as predictor of LVRR
Prevalence of LVRR
28%
n = 57
Mean amplitude of glycemic excursion (MAGE) independent predictor of LVRR, OR (p = 0.002)
0.98
Observational data: associations, not effects.
Further findings
MACE (CV death, ACS recurrence, non-fatal stroke, HF hospitalization) · median follow-up 65 months · lower with LVRR
P = 0.016
- MACE (CV death, ACS recurrence, non-fatal stroke, HF hospitalization) — Patients with MACE
- 20
Original publication
Prognostic importance of glycemic variability on left ventricular reverse remodeling after the first episode of ST-segment elevation myocardial infarction. Cardiovasc Diabetol. Published 4 August 2023. doi:10.
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