PRL-R Variants Are Not Only Associated With Prolactinomas But Also With Dopamine Agonist Resistance
Authors' conclusion
The prolactin/prolactin receptor system seems to be related to prolactinoma tumorigenesis and cabergoline resistance. Additional studies are needed to better understand the PRL-R variants' role and their potential as therapeutic targets.
Study context
- Population
- Adults with sporadic prolactinomas treated with cabergoline, Neuroendocrinology Unit, Clinics Hospital, University of São Paulo, Brazil
- Exposure
- PRL-R variant carriers vs non-carriers
- Outcome
- PRL-R variants and their associations
Methodological detailsobservational, retrospective, single-centre, tertiary referral center
- Observational
- Retrospective
- Single-centre
- Tertiary referral center
Main finding
As reported in the abstract
- PRL-R variants found
- 6
- PRL-R variants associated with male sex
- P = 0.015
- PRL-R variants associated with higher serum PRL levels
- P = 0.007
- PRL-R variants associated with larger tumors
- P = 0.001
- PRL-R variants associated with cabergoline resistance
- P < 0.001
Observational data: associations, not effects.
Original publication
PRL-R Variants Are Not Only Associated With Prolactinomas But Also With Dopamine Agonist Resistance. J Clin Endocrinol Metab. Published 13 January 2023. doi:10.
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