Ectopic lipid deposition and insulin resistance in patients with growth hormone (GH) disorders before and after treatment
Authors' conclusion
GH status is a significant modulator of body composition and insulin sensitivity.GH excess reduces total fat mass and intrahepatic lipid content together with induction of insulin resistance.The data support the notion that GH-induced insulin resistance is unassociated with hepatic lipid accumulation.
Study context
- Population
- Patients with acromegaly or adult GH deficiency (GHD); body composition by DXA, intrahepatic lipid by MR spectroscopy, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR)
- Participants
- 21 / 12 / 12
- Exposure
- Acromegaly and adult GHD at diagnosis vs after treatment
- Acromegalyn = 21
- GHDn = 12
- Referencen = 12reference
- Outcome
- Change after treatment: body composition, intrahepatic lipid and HOMA-IR
- Follow-up
- After treatment
Methodological detailsbefore-and-after treatment, reference group
- Before-and-after treatment
- Reference group
Main finding
As reported in the abstract
- Acromegaly: disease control decreased lean body mass
- P < .000
- Acromegaly: disease control increased % total body fat
- P < .000
- GHD: GH replacement increased lean body mass
- P = .007
- GHD: GH replacement decreased % total body fat
- P = .010
- Acromegaly: intrahepatic lipid increased after disease control
- P = .004
- GHD: intrahepatic lipid did not change significantly after GH replacement
- P = .34
- Acromegaly: HOMA-IR improved after disease control
- P < .000
- GHD: HOMA-IR unaltered after GH replacement
- P = .829
Observational data: associations, not effects.
Original publication
Ectopic lipid deposition and insulin resistance in patients with GH disorders before and after treatment. Eur J Endocrinol. Published 11 January 2023. doi:10.
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