Primary Hyperparathyroidism: Assessment of the Effects of Parathyroidectomy Using Dual X-Ray Absorptiometry, Trabecular Bone Score, and Dual X-Ray Absorptiometry–Based Three-Dimensional Modeling
Authors' conclusion
We found a benefit of parathyroidectomy for bone, with significant percent increases in LS, FN, and TH BMD up to the third year after surgery, and a qualitative benefit for the hip in both its trabecular and cortical compartments and bone strength.
Study context
- Population
- Patients with PHPT undergoing parathyroidectomy (60 women, 25 men; 60.4 ± 12.5 years)
- Participants
- 85 patients
- Exposure
- Before vs after parathyroidectomy
- Outcome
- Mean percent changes in BMD (LS, FN, TH, 1/3 radius), TBS and 3D-DXA parameters (trabecular, cortical and integral vBMD, cortical sBMD, cortical thickness at TH)
- Follow-up
- 12, 24, and/or 36 months after surgery
Main finding
As reported in the abstract
BMD, TBS and 3D-DXA changes after parathyroidectomy · first 3 years after surgery
- Significant mean increases in LS, FN and TH bone mineral density (BMD)
- P < .001
Observational data: associations, not effects.
Further findings
Determinants of percent changes
- Age and preoperative serum PTH and CTX significantly associated with percent changes after surgery
Original publication
Primary Hyperparathyroidism: Assessment of the Effects of Parathyroidectomy Using Dual X-Ray Absorptiometry, Trabecular Bone Score, and Dual X-Ray Absorptiometry–Based Three-Dimensional Modeling. Endocr Pract. Published 5 January 2024. doi:10.
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