Primary hyperparathyroidism and fracture probability
Authors' conclusion
The risk of hip and other major osteoporotic fracture is increased in PHPT irrespective of the disease severity. Fracture probability was attenuated due to the competing effect of mortality.
Study context
- Population
- Patients with primary hyperparathyroidism (PHPT) and matched controls identified from hospital registers in Denmarkmatched cohort
- Participants
- 6,884 vs 68,665
- Exposure
- PHPT vs matched population controls
- PHPTn = 6,884
- Population controlsn = 68,665reference
- Outcome
- Incidence of death, hip fracture and major osteoporotic fracture, and fracture probabilities, excluding time after parathyroidectomy
Methodological detailsmatched population controls, Denmark
- Matched population controls
- Denmark
Main finding
As reported in the abstract
Risk vs population controls, excluding time after parathyroidectomy
Higher risk of death in PHPT
+52%
Higher risk of hip fracture in PHPT
+48%
Higher risk of major osteoporotic fracture in PHPT
+36%
Observational data: associations, not effects.
Further findings
Gradient of fracture risk with differences in bone mineral density (BMD)
- Similar in cases and controls
Patients not undergoing parathyroidectomy (subgroup)
- Results similar
Fracture probability by disease severity
- Decreased with severity, due to increased mortality rather than fracture risk
Original publication
Primary hyperparathyroidism and fracture probability. Osteoporos Int. Published 16 December 2022. doi:10.
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