Prevalence, Progression, and Modifiable Risk Factors for Diabetic Retinopathy in Youth and Young Adults With Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study
Authors' conclusion
Extrapolated to all youth-onset diabetes in the U.S., we estimate 110,051 cases of DR developing within ∼12 years postdiagnosis. Tight glucose and blood pressure management may offer the opportunity to mitigate development and progression of DR in youth-onset diabetes.
Study context
- Population
- Youth and young adults with youth-onset type 1 or type 2 diabetes, SEARCH for Diabetes in Youth Study (2002–2019)
- Participants
- 2,519 vs 447
- Exposure
- Youth-onset T1D vs T2D
- Type 1 diabetesn = 2,519
- Type 2 diabetesn = 447
- Outcome
- Prevalence of DR (mild or moderate nonproliferative DR or proliferative retinopathy)
- Follow-up
- Mean (SD) 12.5 (2.2) years from diagnosis
Methodological detailsmulticenter, population-based
- Multicenter
- Population-based
Main finding
As reported in the abstract
DR prevalence · mean 12.5 years from diagnosis
Observational data: associations, not effects.
Further findings
Risk factors for DR at follow-up
- Higher baseline A1C, increase in A1C, and increase in diastolic and systolic BP associated with DR at follow-up in both diabetes types
- BMI z score and waist/height ratio inconsistently associated (positive and inverse)
- Inverse probability weighting for censoring
DR progression
- Increase in A1C across follow-up associated with retinopathy progression
Extrapolated US burden of DR · ∼12 years postdiagnosis
- Estimated cases of DR in all US youth-onset diabetes
- 110,051
Original publication
Prevalence, Progression, and Modifiable Risk Factors for Diabetic Retinopathy in Youth and Young Adults With Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study. Diabetes Care. Published 12 April 2023. doi:10.
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