Prevalence of Hypercortisolism in Hypertension and Its Link to Carotid Atherosclerosis Markers
Authors' conclusion
Hypercortisolism was detected in 7.5% of nondiabetic and nonobese hypertensive patients and was associated with early vascular damage. Hypercortisolism may worsen the cardiometabolic risk in hypertension.
Study context
- Population
- Nondiabetic, nonobese hypertensive patients aged 37–70 years (53 females)
- Participants
- 106 participants
- Exposure
- Hypertensive patients with vs without hypercortisolism
- Hypercortisolismn = 8
- Outcome
- Prevalence of hypercortisolism (cortisol after 1 mg dexamethasone suppression test >1.8 μg/dL)
Main finding
As reported in the abstract
Hypercortisolism identified
8 patients
7.5%
Observational data: associations, not effects.
Further findings
Age · older with hypercortisolism
P = 0.04
FPG · higher with hypercortisolism
P = 0.03
HbA1c · higher with hypercortisolism
P = 0.001
Altered BP dipping pattern
P = 0.026
Pathologic cIMT (>1 mm)
P = 0.001
Required ≥2 antihypertensive drugs
P = 0.027
Association of F-1mgDST levels with pathologic carotid intima-media thickness (cIMT)
| OR (95% CI) | P value | ||
|---|---|---|---|
| F-1mgDST levels | 14.00 (2.70–72.48) | P < 0.002 | |
| 0.050.21520Odds ratio (log scale) |
F-1mgDST cut-off 1.14 μg/dL (31.4 nmol/L) predicting cIMT >1 mm
| OR (95% CI) | P value | ||
|---|---|---|---|
| F-1mgDST ≥1.14 μg/dL | 15.57 (2.88–84.29) | P = 0.001 | |
| 0.050.21520Odds ratio (log scale) |
- F-1mgDST cut-off 1.14 μg/dL (31.4 nmol/L) predicting cIMT >1 mm — Optimal F-1mgDST cut-off for predicting increased cIMT
- 1.14 μg/dL (31.4 nmol/L)
- Association of F-1mgDST levels with pathologic cIMT: adjusted for age, sex, BMI, smoking, impaired fasting glucose (FG)/impaired glucose tolerance
- F-1mgDST cut-off 1.14 μg/dL (31.4 nmol/L) predicting cIMT >1 mm: adjusted for age, sex, BMI, smoking, impaired glucose metabolism
Original publication
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