A Retrospective Study on the Impact of Primary Aldosteronism in Pregnancy (H.A.P.P.I. Study Group)
Authors' conclusion
A trend towards an increased incidence of postpartum and severe pre-eclampsia was noted in the PA group.
Study context
- Population
- Pregnancies 2011–2022 at the Centre Hospitalier Universitaire de Sherbrooke, screened for primary aldosteronism (PA) with aldosterone-to-renin ratio (ARR) within a 5-year period; >2 fetuses and other endocrinopathies excluded
- Participants
- 226 pregnancies
- Exposure
- Pregnancies with PA vs without PA
- PAn = 15
- Outcome
- Occurrence of hypertensive disorders of pregnancy (HDP) in PA
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Pre-eclampsia
P = 0.252
- Gestational hypertension: PA 0.0% vs 16.6%
- P = 0.136
Observational data: associations, not effects.
Further findings
Post-partum HDP
P = 0.093
IV antihypertensive treatment required
P = 0.216
ICU admission
P = 0.113
Original publication
A Retrospective Study on the Impact of Primary Aldosteronism in Pregnancy (H.A.P.P.I. Study Group). Clin Endocrinol (Oxf). Published 26 October 2025. doi:10.
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