Prevalence and outcome of secondary hypogonadism in male patients with Cushing's syndrome and mild autonomous cortisol secretion
Authors' conclusion
Secondary hypogonadism is common in men with CS and MACS but usually reversible after successful surgery. The persisting changes observed in RBC parameters need to be further investigated in larger cohorts and longer follow-up durations.
Study context
- Population
- Treatment-naïve adult men with Cushing's syndrome (CS) or MACS diagnosed since 2012
- Exposure
- Men with CS or MACS vs age- and BMI-matched controls
- CSn = 30
- MACSn = 17
- Outcome
- Prevalence of secondary hypogonadism (SH) (TT <10.4 nmol/L and age-specific cut-offs)
- Follow-up
- Baseline
Methodological detailsage- and BMI-matched controls, longitudinal analysis
- Age- and BMI-matched controls
- Longitudinal analysis
Main finding
As reported in the abstract
SH prevalence
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| TT, bioavailable T and free TCS vs Controls · lower with CS | P < 0.0001 |
Total testosterone (TT), bioavailable T and free T
- Lowest concentrations in ectopic CS
- TT lower in men with MACS vs controls
Correlation of testosterone with cortisol
- Testosterone correlated negatively with late night salivary cortisol and serum cortisol pre- and post-1 mg dexamethasone suppression test
TT after successful surgery (CS in remission) · 6, 12 and 24 months
- TT increased significantly, normalising within 6 months
- P = 0.001
- Several RBC parameters remained lower in men with CS even 2 years after successful surgery
- Longitudinal analysis, n=20
Original publication
Prevalence and outcome of secondary hypogonadism in male patients with Cushing's syndrome and mild autonomous cortisol secretion. Eur J Endocrinol. Published 29 July 2024. doi:10.
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