Prevalence and Incidence of Hypoglycaemia Among Patients With Type 2 Diabetes in China—A Prospective Cohort Study
Authors' conclusion
Although the prevalence and incidence of hypoglycaemia among Chinese T2D patients were lower than previous studies, hypoglycaemia still remains a significant clinical concern.
Study context
- Population
- Adults with T2D, 103 hospitals in 20 provinces in China, 18 March 2022 to 5 December 2023completed Week 12 follow-up
- Participants
- 15,437 adults
- Exposure
- Neither insulin nor secretagogues vs Secretagogues without insulin vs Insulin
- Outcome
- Prevalence of patients with ≥1 hypoglycaemic event and the corresponding incidence
- Follow-up
- 12 weeks
Methodological detailsmulticentre, non-interventional, 12-week
- Multicentre
- Non-interventional
- 12-week
Main finding
As reported in the abstract
Prevalence of ≥1 hypoglycaemic event
9.0%
95% CI 8.6, 9.5
Incidence rate, events per 100 person-years
79.8
95% CI 76.9, 82.8
Observational data: associations, not effects.
Further findings
Any hypoglycaemia by treatment background · 12 weeks
Incidence rate (events per 100 person-years) Neither insulin nor secretagogues 48.6 · Secretagogues without insulin 105.0 · Insulin 104.3
Any hypoglycaemia by treatment background · 12 weeks
- Similar treatment-related patterns for laboratory-confirmed, symptomatic and nocturnal hypoglycaemia
Hypoglycaemia by patient and setting factors
- Burden varied substantially across age, diabetes duration, body mass index (BMI), HbA1c, geographic region and hospital level
- Greater burden generally with longer diabetes duration and lower BMI
- Prevalence highest in eastern region and tertiary hospitals; incidence rate highest in western regions and primary hospitals
Original publication
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