Pregnancy and Progression of Differentiated Thyroid Cancer: A Propensity Score–Matched Retrospective Cohort Study
Main finding · DTC progression-free survivalResult — go to the resultHR for DTC progression 0.96 95% CI 0.56–1.65Authors' conclusion
Pregnancy seemed to be irrelevant to DTC progression-free survival before surgical treatment. Further prospective cohort studies are needed to translate this finding into clinical practice.
Study context
- Population
- Women aged 20 to 45 years with differentiated thyroid cancer (DTC) before surgical treatment, Peking University Third Hospital, Beijing, China, 2012–2022
- Participants
- 311 eligible women
- Exposure
- Pregnant vs nonpregnant women with DTC before surgery
- Pregnantn = 48
- Nonpregnantn = 154reference
- Outcome
- DTC progression-free survival
- Follow-up
- Average observation 2.5 years
Methodological detailspropensity score matched, single-centre
- Propensity score matched
- Single-centre
Main finding
As reported in the abstract
average observation period of 2.5 years
HR for DTC progression
0.96
95% CI 0.56–1.65
P = 0.895
Pregnantvs Nonpregnant
HR for DTC progression 0.96 (95% CI 0.56–1.65); P = 0.895
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Tumor enlargement-free survival · average observation period of 2.5 years | HR for tumor enlargement 0.99 (95% CI 0.56–1.76) | P = 0.969 | |
| Lymph node metastasis-free survival · average observation period of 2.5 years | HR for lymph node metastasis 0.67 (95% CI 0.21–2.13) | P = 0.498 | |
| 0.20.5125Ratio (log scale) |
| Outcome | P value |
|---|---|
| Postoperative pathological characteristicsNo significant difference | P > 0.05 |
Postoperative pathological characteristics
- No significant difference between pregnant and nonpregnant groups
Original publication
Pregnancy and Progression of Differentiated Thyroid Cancer: A Propensity Score–Matched Retrospective Cohort Study. J Clin Endocrinol Metab. Published 20 September 2023. doi:10.
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