Pregnancy and delivery after surgical remission in women with prolactinomas desiring pregnancy: Refining surgical indications
Authors' conclusion
Pregnancy and delivery following surgical remission were associated with no recurrence, suggesting a potential cure in this subgroup.
Study context
- Population
- Women with prolactinomas undergoing surgery, many desiring pregnancy; 1998–2008 (median age 28.0 years) and 2009–2022 (median age 35.0 years)in remission, both cohorts
- Participants
- 59 women
- Exposure
- Women who conceived and delivered after surgical remission vs women who did not conceive
- Outcome
- Recurrence after surgical remission
Methodological detailstwo cohorts (1998-2008 and 2009-2022)
- Two cohorts (1998-2008 and 2009-2022)
Main finding
As reported in the abstract
P = 0.0237
Observational data: associations, not effects.
Further findings
Recurrence by postoperative prolactin
P = 0.0098
Remission in enclosed-type microadenomas
- Remission, 1998-2008
- 73.8%
- Remission, later period
- 95.2%
Surgery and outcome under refined criteria, 2009-2022
- Underwent surgery
- 25/135 (18.5%)
- Met refined criteria / elected surgery
- 32 / 20
- Remission among those electing surgery
- all 20, without new deficits
Safety
New deficits after surgery (refined criteria)
- New deficits among 20 women electing surgery
- 0
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Pregnancy and delivery after surgical remission in women with prolactinomas desiring pregnancy: Refining surgical indications. Pituitary. Published 25 March 2026. doi:10.
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