Predictors of Fracture in Middle-Aged and Older Adults With Type 2 Diabetes and Overweight or Obesity
Authors' conclusion
Thiazolidinedione and insulin use predict clinical fracture in middle-aged and older persons with type 2 diabetes and overweight or obesity. Evaluating BMD is advisable if these medications are prescribed. Fracture risk prediction tools may consider including thiazolidinedione and insulin use to refine prediction in this population.
Study context
- Population
- Men and women 45 to 75 years old with T2D and BMI ≥ 25 kg/m², multicenter US study; randomization 2001–2004, fracture follow-up until 2015
- Participants
- 4,703 men
- Comparison
- Potential fracture predictors
- Primary endpoint
- All incident clinical fractures, by self-report, centrally adjudicated with medical records review
- Follow-up
- median 12.2-year follow-up
Methodological detailsmulticenter
- Multicenter
Primary result
As reported in the abstract
All clinical fractures
Participants with ≥1 clinical fracture
649 of 4703
Further findings
Total hip bone mineral density (BMD) as predictor of all clinical fractures (subcohort, n = 1285)
- Per 1 SD = 0.1 g/cm² increase in total hip BMD: HR 0.47; 95% CI, 0.39-0.58; strongest modifiable predictor
- Subcohort n = 1285
Original publication
Predictors of Fracture in Middle-Aged and Older Adults With Type 2 Diabetes and Overweight or Obesity. J Clin Endocrinol Metab. Published 11 September 2024. doi:10.
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