Predictive value of baseline thyroid autoantibody titers for ICI-associated thyroid adverse events in cancer
Authors' conclusion
Baseline TPOAb and TgAb titers are effective predictors of thyroid irAEs. Higher TPOAb titers are correlated with an increased risk, thereby supporting the utility of quantitative baseline screening for risk stratification.
Study context
- Population
- Patients with malignancies treated with immune checkpoint inhibitors (ICIs), January 2022–October 2025
- Participants
- 181 patients
- Exposure
- Elevated vs normal baseline thyroid autoantibody titers
- Outcome
- Thyroid immune-related adverse events (irAEs)
Main finding
As reported in the abstract
Thyroid irAEs
- Thyroid immune-related adverse events (irAEs) occurred
- 44 (24.3%)
- Hypothyroidism among thyroid irAEs
- 81.8%
- Baseline thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb) positivity and thyroglobulin antibody (TgAb) positivity were significant risk factors (logistic regression)
- P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Thyroid irAEs by TPOAb titer levelSeverely elevated TPOAb vs Moderately elevated TPOAb · significantly higher risk with severely elevated titers | P < 0.05 |
Thyroid irAEs by TPOAb titer level
- Severely vs moderately elevated TgAb titers: difference not significant
Original publication
Predictive value of baseline thyroid autoantibody titers for ICI-associated thyroid adverse events in cancer. Eur Thyroid J. Published 15 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →