Predictive Value of 1-Hour Glucose Elevations during Oral Glucose Tolerance Testing for Cystic Fibrosis-Related Diabetes
Authors' conclusion
In youth with CF, 1 hG ≥ 140 mg/dl is an early indicator of CFRD risk. However, 2 hG, rather than 1 hG, predicted lung function decline.
Study context
- Population
- Youth with cystic fibrosis with ≥1 oral glucose tolerance test (OGTT) including a 1 hG, 2010–2019; baseline age (mean ± SD) 12.4 ± 2.6 years, follow-up 3.2 ± 1.4 years177 with ≥2 OGTTs
- Participants
- 243 participants
- Exposure
- High vs low 1-hour OGTT glucose
- Outcome
- Progression to CFRD by high vs low 1 hG
Methodological detailssingle-centre, retrospective chart review
- Single-centre
- Retrospective chart review
Main finding
As reported in the abstract
Progression to CFRD · 5 years
Developed cystic fibrosis-related diabetes (CFRD)
28
Average 1 hG when 2 hG ≥ 200 mg/dL
267 mg/dL
Observational data: associations, not effects.
Further findings
- Baseline 2 hG predicted decline in FEV1%predicted, but 1 hG did not
- Mixed-effects models
Original publication
Predictive Value of 1-Hour Glucose Elevations during Oral Glucose Tolerance Testing for Cystic Fibrosis-Related Diabetes. Pediatr Diabetes. Published 17 April 2023. doi:10.
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