Prediabetic HbA1c and Cortical Atrophy: Underlying Neurobiology
Authors' conclusion
Effective glycemia control at prediabetic levels is warranted to preserve brain health and prevent prediabetes-related neurobiologic perturbations.
Study context
- Population
- Adults aged 45 to 81 years (mean ± SD 64 ± 7.5) with brain MRI and blood HbA1c data
- Participants
- 30,579 adults
- Outcome
- Relationship between blood HbA1c and cerebral cortical thickness
Methodological detailsgenome-wide association study, cell-specific gene expression analysis
- Genome-wide association study
- Cell-specific gene expression analysis
Main finding
As reported in the abstract
HbA1c–cortical thickness association
HbA1c–cortical thickness association noncontinuous, emerging negatively within the prediabetic range
39.6 mmol/mol
Observational data: associations, not effects.
Further findings
Regional cell-specific gene expression
- Association strongest in brain regions with higher expression of excitatory neuron-specific genes and lower expression of astrocyte- and microglia-specific genes
Genome-wide association study of shared HbA1c–cortical thickness variance
- A significant locus implicated mitochondrial maintenance and ATP generation
Original publication
Prediabetic HbA1c and Cortical Atrophy: Underlying Neurobiology. Diabetes Care. Published 12 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →