PPI-Induced Changes in Plasma Metabolite Levels Influence Total Hip Bone Mineral Density in a UK Cohort
Authors' conclusion
We suggest here that PPI use may influence total hip BMD, both directly and indirectly, via plasma metabolites involved in the sex hormone pathway.
Study context
- Population
- British male and female individuals, UK cohortmore than 5000
- Exposure
- PPI use vs no PPI use
- Outcome
- BMD
Main finding
As reported in the abstract
- PPI use is associated with decreased lumbar spine and total hip bone mineral density (BMD)
- Effect not mediated through the gut microbiome
- PPI use may influence total hip BMD directly and indirectly via plasma metabolites involved in the sex hormone pathway
Observational data: associations, not effects.
Original publication
PPI-Induced Changes in Plasma Metabolite Levels Influence Total Hip Bone Mineral Density in a UK Cohort. J Bone Miner Res. Published 2 December 2022. doi:10.
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