Postprandial Glucose Excursions with Ultra-Rapid Insulin Analogs in Hybrid Closed-Loop Therapy for Adults with Type 1 Diabetes
Authors' conclusion
The use of Lyumjev with CamAPS FX closed-loop system improved postprandial glucose excursions compared with insulin lispro, while the use of Fiasp did not provide any advantage compared with insulin aspart.
Study context
- Population
- Adults with T1D using CamAPS FX hybrid closed-loop; 7137 eligible meals over 8 weeks
- Participants
- 51 adults2 trials
- Comparison
- Fiasp vs insulin aspart; Lyumjev vs insulin lispro, with CamAPS FX hybrid closed-loop
Methodological detailsdouble-blind, randomized, hybrid closed-loop (CamAPS FX)
- Double-blind
- Randomized
- Hybrid closed-loop (CamAPS FX)
Primary result
As reported in the abstract
Postprandial glucose excursions: iAUC-2h and iAUC-4h, Lyumjev vs insulin lispro · after breakfast
Insulin lispro vs LyumjevMean difference, mmol/L per 2 h (95% CI)P value
iAUC-2h lower with Lyumjev
92(56–127)
P < 0.001Insulin lispro vs LyumjevMean difference, mmol/L per 4 h (95% CI)P value
iAUC-4h lower with Lyumjev
151(74–229)
P < 0.001- iAUC-2h and iAUC-4h significantly decreased with Lyumjev after evening meal
- P < 0.001 and P = 0.011
Further findings
| Outcome | Mean difference (percentage points) (95% CI) | |
|---|---|---|
| 4 h postprandial TIR (3.9-10.0 mmol/L), Lyumjev vs insulin lispro · 4 h postprandiallyLyumjevvs Insulin lisproBreakfast; higher with Lyumjev | 6.7 (3.3–10) | |
| 4 h postprandial TIR (3.9-10.0 mmol/L), Lyumjev vs insulin lispro · 4 h postprandiallyLyumjevvs Insulin lisproEvening meal; higher with Lyumjev | 5.7 (1.4–9.9) | |
| −5051015Difference, percentage points (linear scale) |
| Outcome | P value |
|---|---|
| iAUC-2h, iAUC-4h and other postprandial measures, Fiasp vs insulin aspart · breakfast, lunch and evening mealNo significant differences | P > 0.05 |
iAUC-2h, iAUC-4h and other postprandial measures, Fiasp vs insulin aspart · breakfast, lunch and evening meal
- No significant differences between insulin aspart and Fiasp
Original publication
Postprandial Glucose Excursions with Ultra-Rapid Insulin Analogs in Hybrid Closed-Loop Therapy for Adults with Type 1 Diabetes. Diabetes Technol Ther. Published 27 February 2024. doi:10.
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