Postprandial Glucose Control With Different Hybrid Closed-Loop Systems According to Type of Meal in Adults With Type 1 Diabetes
Authors' conclusion
Independent of different proportions of dietary carbohydrates, fat, and protein, postprandial glucose response was similar in users of different HCLs, although obtained through different automatic insulin delivery patterns.
Study context
- Population
- Adults with T1D using Hybrid Closed-Loop Systems (HCLs); 7-day food records and HCL reports; breakfasts, lunches, dinners split by median C/FP ratiobreakfasts 570 · lunches 658 · dinners 619
- Participants
- 120 adults
- Exposure
- MiniMed670G vs MiniMed780G vs Control-IQ HCL systems, by meal C/FP ratio
- MiniMed670Gn = 40
- MiniMed780Gn = 49
- C-IQn = 31
- Outcome
- Postprandial glucose TIR 70 to 180 mg/dL
- Follow-up
- After breakfast (4-hour), lunch (6-hour), dinner (6-hour)
Main finding
As reported in the abstract
TIR after breakfast
78.3 ± 26.9%
TIR after lunch
72.7 ± 26.1%
TIR after dinner
70.8 ± 27.3%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Late glucose-iAUC · after lunchC-IQ vs MiniMed670G and MiniMed780G · lower with C-IQ, independent of C/FP | P < 0.05 |
| Postprandial insulin pattern (Ins3-6h minus Ins0-3h)MiniMed670G, MiniMed780G and C-IQ · differed by HCL type at lunch | P = 0.026 |
| Postprandial insulin pattern (Ins3-6h minus Ins0-3h)MiniMed670G, MiniMed780G and C-IQ · differed by HCL type at dinner | P < 0.001 |
Late glucose-iAUC · after lunch
- No significant differences at breakfast and dinner
Postprandial insulin pattern (Ins3-6h minus Ins0-3h)
- Early insulin dose (Ins0-3h) higher than late dose (Ins3-6h) in 670G and 780G users; opposite pattern in C-IQ users
Original publication
Postprandial Glucose Control With Different Hybrid Closed-Loop Systems According to Type of Meal in Adults With Type 1 Diabetes. J Diabetes Sci Technol. Published 5 June 2024. doi:10.
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