Postoperative osteoporosis therapy and risk of re-fracture in elderly patients with hip fractures: a multicenter retrospective cohort study
Authors' conclusion
Postoperative osteoporosis therapy significantly lowers refracture risk and delays contralateral hip fracture.
Study context
- Population
- Patients aged ≥ 65 years who underwent hip fracture surgery, January 2010–December 2024, three teaching hospitalsafter matching
- Participants
- 1,986 patients
- Exposure
- Guideline-recommended postoperative osteoporosis therapy vs no treatment
- Outcome
- Refracture
Methodological detailsmulticentre, propensity-score matched (1:1), Kaplan-Meier analysis and Cox regression
- Multicentre
- Propensity-score matched (1:1)
- Kaplan-Meier analysis and Cox regression
Main finding
As reported in the abstract
- Refracture rate, osteoporosis treatment vs no treatment, p < 0.001
- 22.6% vs. 39.3%
- Osteoporosis therapy, refracture risk HR (95% CI 0.07-0.18, p < 0.001); 89% relative reduction
- 0.11
Observational data: associations, not effects.
Further findings
Median refracture-free survival
P < 0.001
Time to contralateral hip fracture (sub-cohort with bilateral hip fractures, n=192)
P < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Postoperative osteoporosis therapy and risk of re-fracture in elderly patients with hip fractures: a multicenter retrospective cohort study. Osteoporos Int. Published 1 December 2025. doi:10.
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