Positive effects of ketogenic diet on weight control in children with obesity due to Prader–Willi syndrome
Authors' conclusion
Our results indicate that KD might have a favourable effect on weight management in PWS.
Study context
- Population
- Children with Prader-Willi syndrome (PWS) who received ketogenic diet (KD) for at least 6 months; median age 52.5 (47–77) months
- Participants
- 10 children
- Exposure
- Before vs after ketogenic diet
- Outcome
- Body weight SD score
- Follow-up
- Median treatment period 16.5 [11-52] months
Methodological details75%-85% of daily calories from fat, 15%-25% from protein + carbohydrate
- 75%-85% of daily calories from fat, 15%-25% from protein + carbohydrate
Main finding
As reported in the abstract
Baseline
2.10
range −1.11–4.11
Final evaluation
0.05
range −0.92–1.2
P = 0.007
Observational data: associations, not effects.
Further findings
| Outcome | Baseline | Final evaluation | P value |
|---|---|---|---|
| BMI SD score | median 3.05 (range −0.21–3.72) | 0.41 (range −0.87–1.57) | P = 0.002 |
Height SD score
- The height SD score remained unchanged
Safety
Biochemical abnormalities
- Mild hypercholesterolaemia was the most common biochemical abnormality during KD
Original publication
Positive effects of ketogenic diet on weight control in children with obesity due to Prader–Willi syndrome. Clin Endocrinol (Oxf). Published 25 December 2022. doi:10.
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