Polygenic Scores for Adult Testosterone and Sex Hormone-binding Globulin (SHBG) Levels Are Associated With Reproductive Hormone Levels in Male Infants
Authors' conclusion
Our findings suggest that the genetic architecture underlying total T and SHBG in adults also associates with hormone concentrations and their trajectories during infancy.
Study context
- Population
- Healthy, male, term, singleton newborns followed with repeated clinical examinations incl. blood sampling during 1-year follow-up (COPENHAGEN Minipuberty Study, 2016–2018)
- Participants
- 109 participants
- Outcome
- Circulating reproductive hormone concentrations (mean SD scores (SDS) in infancy) and their association with UK Biobank-based polygenic scores (PGS) of adult total T and SHBG
- Follow-up
- 1-year follow-up
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Association of adult PGS with mean hormone SDS in infancy
- T-PGSadult with mean T-SDSinfancy
- P = .02, r2 = 0.05
- T-PGSadult with mean SHBG-SDSinfancy
- P <.001, r2 = 0.21
- T-PGSadult with mean LH-SDSinfancy
- P = .03, r2 = 0.04
- SHBG-PGSadult with mean SHBG-SDSinfancy
- P < .001, r2 = 0.18
- Phenotypic variation in infancy explained by T-PGSadult: mean T-SDSinfancy and SHBG-SDSinfancy
- 5% and 21%
Observational data: associations, not effects.
Original publication
Polygenic Scores for Adult Testosterone and SHBG Levels Are Associated With Reproductive Hormone Levels in Male Infants. J Clin Endocrinol Metab. Published 27 February 2024. doi:10.
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