Platelet Function and Markers of Atherothrombotic Risk in Individuals With Parathyroid Disorders
Authors' conclusion
PHPT and HypoPT patients have increased markers of atherothrombotic risk due to endothelial and platelet function alterations. Our results suggests that parathyroid hormone may influence platelet reactivity. Further research is needed to determine if personalized antiplatelet therapy is necessary in individuals with parathyroid disorders.
Study context
- Population
- Individuals with hypoparathyroidism (HypoPT) or primary hyperparathyroidism (PHPT) and matched controls at an outpatient clinic
- Participants
- 40 / 40 / 40
- Exposure
- HypoPT vs PHPT vs controls
- HypoPTn = 40
- PHPTn = 40
- Controlsn = 40reference
- Outcome
- Circulating markers of oxidative stress, endothelial function and platelet activation, calcium metabolism parameters, FMD and carotid IMT
Methodological detailsmonocentric, age- and sex-matched controls
- Monocentric
- Age- and sex-matched controls
Main finding
As reported in the abstract
Oxidative stress, endothelial and platelet function
- PHPT showed the highest reduction of FMD (P < .001 and P = .001) and a marked increase of intimal-media thickness (IMT) (P < .001 and P = .001)
- Increased soluble P selectin and thromboxane B2 in patients with parathyroid disorders
- HypoPT vs Controls: P < 0.001
- PHPT vs Controls: P < 0.001
- PHPT vs HypoPT: P < 0.001 vs HypoPT and controls
- PHPT vs Controls: P < 0.001 vs HypoPT and controls
- PHPT vs Controls: P < 0.001, PHPT vs controls
- HypoPT vs Controls: P = 0.006, HypoPT vs controls
- PHPT vs HypoPT: P < 0.001, PHPT vs HypoPT
Observational data: associations, not effects.
Original publication
Platelet Function and Markers of Atherothrombotic Risk in Individuals With Parathyroid Disorders. J Clin Endocrinol Metab. Published 4 March 2025. doi:10.
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