Plasma Proteomics of Diabetic Kidney Disease Among Asians With Younger-Onset Type 2 Diabetes
Authors' conclusion
Large-scale proteomic analysis identified novel proteomic biomarkers for DKD progression in YT2D. Genetic evidence suggest a causal role of plasma angiogenin in DKD progression.
Study context
- Population
- Asians with younger-onset T2D (onset age <40 years)matched case-control
- Participants
- 144 vs 292
- Comparison
- Diabetic kidney disease (DKD) progressors vs nonprogressors
- Progressorsn = 144
- Nonprogressorsn = 292reference
- Outcome
- Plasma proteins associated with DKD progression (eGFR decline ≥3 mL/min/1.73 m² or 40% decline from baseline)
Methodological detailsmatched for T2D onset age, sex and ethnicity, discovery and validation sets, proximity extension assay proteomics (1472 plasma proteins), multivariable logistic regression
- Matched for T2D onset age, sex and ethnicity
- Discovery and validation sets
- Proximity extension assay proteomics (1472 plasma proteins)
- Multivariable logistic regression
Main finding
As reported in the abstract
Plasma proteins associated with DKD progression
Plasma proteins associated with DKD progression, independent of traditional cardiorenal risk factors, baseline estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio
42
Angiogenin (top signal), OR
5.29; 95% CI, 2.39-11.73
P = 4.03 × 10-5
Observational data: associations, not effects.
Further findings
Mendelian randomization (MR): genetically determined plasma angiogenin and DKD progression
- Genetically determined plasma angiogenin level associated with increased odds of DKD progression
Original publication
Plasma Proteomics of Diabetic Kidney Disease Among Asians With Younger-Onset Type 2 Diabetes. J Clin Endocrinol Metab. Published 16 April 2024. doi:10.
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