Plasma Levels of Small High-density Lipoprotein (HDL) Particles Are Associated With Coronary Atherosclerosis Progression in Adults With Diabetes
Main finding · CAC incidence/progressionResult — go to the resultGreater likelihood 140% 95% CI 32%–341%Authors' conclusion
HDLp1 concentration is significantly associated with CAC incidence/progression in individuals with T2DM and may improve risk discrimination for coronary atherosclerosis progression in this population.
Study context
- Population
- Non-statin users with T2D and no baseline atherosclerotic CVD, ELSA-Brasil cohort461 in T2D subgroup
- Participants
- 4,331 users
- Exposure
- Third vs first tertile of small HDL particle concentration
- Outcome
- CAC incidence/progression
Methodological detailsELSA-Brasil cohort
- ELSA-Brasil cohort
Main finding
As reported in the abstract
Greater likelihood
140%
95% CI 32%–341%
P < 0.001
- Coronary artery calcium (CAC) incidence/progression among 461 non-statin users with T2D
- 143 (31.0%)
Observational data: associations, not effects.
Further findings
CAC risk classification with HDLp1 added
- Net reclassification improvement (NRI)
- 13.6% (95% CI, 2.8%-18.8%; P = .004)
CAC incidence/progression, T2D vs no diabetes
- Increased CAC incidence/progression rates with T2D vs nondiabetic participants
Original publication
Plasma Levels of Small HDL Particles Are Associated With Coronary Atherosclerosis Progression in Adults With Diabetes. J Clin Endocrinol Metab. Published 3 April 2025. doi:10.
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