Gestational diabetes & diabetes in pregnancy
Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes
Authors' conclusion
These results implicate IGFBP1 in the glycemic physiology of pregnancy and suggest a role for placental IGFBP1 deficiency in GDM pathogenesis.
Study context
- Population
- Pregnant women; 434 human placentas profiled, plus additional pregnancy cohorts
- Participants
- 434 placentas
- Outcome
- Placental IGFBP1 and insulin sensitivity
- Follow-up
- ≈26 weeks gestation
Methodological detailstranscriptomic profiling, multiple pregnancy cohorts
- Transcriptomic profiling
- Multiple pregnancy cohorts
Main finding
As reported in the abstract
~26 weeks gestation
- Positive association between placental IGFBP1 expression and insulin sensitivity
- Higher circulating IGFBP1 associated with greater insulin sensitivity (lesser insulin resistance), in the same cohort and in two additional pregnancy cohorts
- Low circulating IGFBP1 in early pregnancy predicted subsequent gestational diabetes mellitus (GDM) diagnosis in two cohorts
Further findings
- Circulating IGFBP1 rose over pregnancy and declined postpartum, suggesting a placental or decidual source
Original publication
Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes. Nat Med. Published 16 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →