Diabetes complications

Peripheral nerve enlargement in patients with diabetic sensorimotor polyneuropathy: A systematic review and meta-analysis

Diabetes Res Clin PractPublished Systematic review and meta-analysis

Pooled result · Peripheral nerve CSAResult — go to the resultPooled mean difference + 5.26 mm² 95% CI 0.94–9.57

Authors' conclusion

In conclusion, peripheral nerve CSA is increased in diabetes and further enlarged in the presence of DSP, with the largest effects at distal compression sites.

Study context

Population
Ultrasound studies measuring peripheral nerve cross-sectional area (CSA) in patients with diabetes with and without DSP; PubMed and Embase41 studies in meta-analyses
Comparison
Diabetes with DSP vs diabetes without DSP vs healthy controls
Outcome
Weighted inter-group mean difference in CSA at all reported upper- and lower extremity sites

Pooled result

Peripheral nerve CSA

Pooled mean difference

+ 5.26 mm²

95% CI 0.94–9.57

As reported in the abstract

Original publication

Peripheral nerve enlargement in patients with diabetic sensorimotor polyneuropathy: A systematic review and meta-analysis. Diabetes Res Clin Pract. Published 24 March 2026. doi:10.1016/j.diabres.2026.113226

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