Peripheral nerve conduction in youth with type 1 diabetes: A longitudinal analysis of clinical and glycemic predictors
Authors' conclusion
NCS may detect electrophysiological abnormalities consistent with early nerve dysfunction in pediatric type 1 diabetes. Motor parameters may show earlier vulnerability and relate to cumulative glycemic exposure, whereas sensory axonal involvement may be linked to longer disease duration.
Study context
- Population
- Children and adolescents with T1D (mean age 14.0 ± 3.5 years; diabetes duration 6.5 ± 3.5 years)96 with paired exams
- Participants
- 207 children
- Outcome
- Associations of nerve conduction parameters with clinical and glycemic variables
Main finding
As reported in the abstract
Older age and lower peroneal motor conduction velocity (MCV) (B; p = 0.001)
−0.59
Male sex and higher compound muscle action potential (CMAP) (B; p = 0.030)
2.04
Higher 5-year mean HbA1c and lower CMAP (B; p < 0.001)
−3.72
Observational data: associations, not effects.
Further findings
Predictors of within-patient deterioration · 2 years
- Higher mean sensor glucose and peroneal MCV decline (OR; p = 0.025)
- 1.13
- Longer diabetes duration and sensory nerve action potential (SNAP) deterioration (OR; p = 0.021)
- 1.32
- Logistic regression
Original publication
Peripheral nerve conduction in youth with type 1 diabetes: A longitudinal analysis of clinical and glycemic predictors. Diabet Med. Published 11 July 2026. doi:10.
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