Perioperative teriparatide for preventing proximal junctional kyphosis and failure in patients with osteoporosis after adult thoracolumbar spinal deformity surgery: a prospective randomized controlled trial
Authors' conclusion
Perioperative teriparatide treatment of patients with osteoporosis after ASD surgery effectively reduced PJF incidence and postoperative back pain.
Study context
- Population
- Patients with osteoporosis planned to undergo adult spinal deformity (ASD) surgery
- Participants
- 64 patients
- Comparison
- Perioperative teriparatide vs denosumab (active control), from 3 months preoperatively to 3 months postoperatively
- Primary endpoint
- Proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) incidence within 1 year after ASD surgery
- Follow-up
- 1 year
Methodological detailsprospective, active-controlled
- Prospective
- Active-controlled
Primary result
As reported in the abstract
PJK incidence · within 1 year
P = 0.165
Secondary outcomes
PJF incidence (co-primary) · within 1 year · modified intention-to-treat (mITT) analysis
P = 0.034
Bone mineral density (BMD) of the hip · 1-year follow-up
- No significant differences between the two groups
Postoperative VAS for back pain and EQ-5D score
- Significantly improved in the teriparatide group
Original publication
Perioperative teriparatide for preventing proximal junctional kyphosis and failure in patients with osteoporosis after adult thoracolumbar spinal deformity surgery: a prospective randomized controlled trial. Osteoporos Int. Published 18 March 2025. doi:10.
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