Perioperative glycaemic profiles in Aboriginal and Torres Strait Islander people with diabetes mellitus
Authors' conclusion
Despite being 14 years younger and having greater preoperative comorbidity and higher HbA1c levels, Aboriginal and Torres Strait Islander people demonstrated higher rates of perioperative hypoglycaemia, but otherwise broadly comparable perioperative glycaemic profiles to their non-Indigenous Australian counterparts. Further research should ideally be Indigenous-led, and prospectively evaluate interventions to both reduce cumulative glycaemic burden and optimise perioperative glycaemia using modern diabetes technologies in Aboriginal and Torres Strait Islander people both with and without diabetes mellitus.
Study context
- Population
- Adults with DM undergoing surgery in South Australia (2018–2023)
- Participants
- 16,396 adults
- Exposure
- Aboriginal and Torres Strait Islander people vs non-Indigenous Australians
- Aboriginal and Torres Strait Islander peoplen = 1,065
- Outcome
- Perioperative glycaemic profiles
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Mean blood glucose levels (BGL), glycaemic variability and glycaemic ratios similar; higher hypoglycaemia in Aboriginal and Torres Strait Islander people, coinciding with greater inpatient use of sulphonylureas and insulin
- Aboriginal and Torres Strait Islander people vs Non-Indigenous Australians: P = 0.032
- Aboriginal and Torres Strait Islander people vs Non-Indigenous Australians: P = 0.045
- Aboriginal and Torres Strait Islander people vs Non-Indigenous Australians: P = 0.382
- Aboriginal and Torres Strait Islander people vs Non-Indigenous Australians: P < 0.001
Observational data: associations, not effects.
Further findings
Baseline characteristics
P < 0.001
Baseline characteristics
P < 0.001
Baseline characteristics
P < 0.001
| Outcome | P value |
|---|---|
| Baseline characteristics54.3 vs. 68.2 years; younger | P < 0.001 |
| Baseline characteristics68.5 mmol/L (8.4%) vs. 62.1 mmol/mol (7.8%); higher | P < 0.001 |
Safety
Perioperative hypoglycaemia
P < 0.001
Original publication
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