People With Diabetes and Caregivers Prefer Rescue Glucagon Treatment With a Wider Storage Temperature Range and a Nasal Administration, When Efficacy is Similar: A Discrete Choice Experiment in Spain
Authors' conclusion
Adults with diabetes and caregivers prefer a glucagon treatment with a higher rate of successful administration, wider storage temperature, and nasal delivery method, when efficacy is similar. Participants favored NG over conventional IG as a rescue medication for severe hypoglycemia. This information may help decision-making by payers and treatment discussions between health care professionals and patients.
Study context
- Population
- Adults with diabetes and caregivers in Spain; mean age 40 years, 51% female276 adults with diabetes, 270 caregivers
- Comparison
- Nasal glucagon vs conventional injectable glucagon medication profiles
- Outcome
- Relative attribute importance (RAI) of glucagon treatment attributes
Methodological detailsonline
- Online
Main finding
As reported in the abstract
RAI of attributes
- Storage temperature, relative attribute importance (RAI)
- 27.3% (95% CI 22.9-32.2)
- Delivery method, RAI
- 17.4% (95% CI 13.1-21.9)
- Headache risk, RAI
- 16.2% (95% CI 11.8-20.7)
- Time to prepare and administer, RAI
- 14.5% (95% CI 10.1-18.8)
- Glucagon preparation, RAI
- 11.4% (95% CI 6.8-15.8)
- Recovery time, RAI
- 8.9% (95% CI 4.3-13.3)
- Device size, RAI
- 4.3% (95% CI 0.3-8.8)
Further findings
- Preference for nasal glucagon (NG) vs injectable glucagon (IG) profiles — Participants preferring NG over IG profiles · 78% of participants preferred NG profiles
- 78% · P < 0.001
Original publication
People With Diabetes and Caregivers Prefer Rescue Glucagon Treatment With a Wider Storage Temperature Range and a Nasal Administration, When Efficacy is Similar: A Discrete Choice Experiment in Spain. J Diabetes Sci Technol. Published 9 May 2022. doi:10.
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