Patient-derived medullary thyroid cancer organoids: a potential model for mechanistic studies on diagnostics and therapy
Authors' conclusion
We were able to culture MTC organoids that resemble the original tissue in gene expression, protein expression, and functionality. However, international, multi-center studies are required to meet the standards for future clinical applications.
Study context
- Population
- Medullary thyroid carcinoma (MTC) biopsies from patients with medullary thyroid carcinoma
- Participants
- 10 MTC biopsies
- Outcome
- Establishment of an MTC organoid model
Methodological detailspatient-derived organoid model, proof-of-principle experiments
- Patient-derived organoid model
- Proof-of-principle experiments
Main finding
As reported in the abstract
- MTC biopsies successfully cultured as MTC-organoids (MTOs)
- 10
Further findings
Proof-of-principle exposure of MTOs to tyrosine kinase inhibitors (TKIs) and PET tracers
- Interpretation limited by sample size but demonstrates future potential
- Preliminary experiments
Original publication
Patient-derived medullary thyroid cancer organoids: a potential model for mechanistic studies on diagnostics and therapy. Eur Thyroid J. Published 18 August 2025. doi:10.
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