Parathyroidectomy Reduces Inflammatory Cytokines and Increases Vitamin D Metabolites in Patients With Primary Hyperparathyroidism
Authors' conclusion
These findings suggest that PTH may upregulate the production of MCP-1 and IL-6 and downregulate circulating DBP in patients with PHPT that are normalized by PTX. The exact mechanism of IL-6 and MCP-1 on DBP, vitamin D metabolites, and clinical outcomes in patients with PHPT is an area requiring further study.
Study context
- Population
- Newly diagnosed patients with primary hyperparathyroidism (PHPT)28 returned after PTX
- Participants
- 70 vs 70
- Exposure
- PHPT before vs after PTX; PHPT vs healthy controls
- PHPTn = 70
- Controlsn = 70reference
- Outcome
- Effect of PTX on inflammatory profiles, total and free 25OHD, and DBP
- Follow-up
- 3 months after PTX
Methodological detailsbefore-after, age and BMI-matched healthy controls
- Before-after
- Age and BMI-matched healthy controls
Main finding
As reported in the abstract
- PTX increased total and free 25OHD and D binding protein (DBP)
- P < .001
- PTX decreased serum IL-6 and MCP-1
- P < .05
Observational data: associations, not effects.
Further findings
Serum DBP before PTX vs controls · lower in PHPT
P < 0.001
Total 25OHD before PTX vs controls · lower in PHPT
P < 0.05
- Cytokines before PTX vs controls · serum IL-6, C-reactive protein and MCP-1 higher in PHPT
- P < 0.05
Total 25OHD before PTX vs controls
- Free 25OHD similar to controls
Cytokines before PTX vs controls
- Interleukin-10 similar to controls
Preoperative parathyroid hormone (PTH) and variance of IL-6 and MCP-1 (multiple regression)
- Preoperative PTH explained a significant portion of the variance of IL-6 and MCP-1
- P < 0.05
Original publication
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