Pain, Quality of Life, and Mental Health in Adults with X-linked Hypophosphatemia: A Cross-sectional Study
Authors' conclusion
Our results suggest that using patient-reported outcomes is important to understand the pain phenotype and mental health in patients with XLH and can be helpful to dictate treatment aimed at improving their pain and quality of life.
Study context
- Population
- Adults with X-linked hypophosphatemia (XLH) and healthy sex- and age-matched controls
- Participants
- 49 vs 42
- Exposure
- Adults with XLH vs healthy matched controls
- XLHn = 49
- Controlsn = 42reference
- Outcome
- Pain sensitivity (pressure algometry) and patient-reported pain, QoL and mental health
Methodological detailssex- and age-matched healthy controls
- Sex- and age-matched healthy controls
Main finding
As reported in the abstract
- Altered skin but not bone mechanical pressure pain thresholds in XLH
- Significantly higher pain scores in XLH, correlating with depression scores
- XLH: decreased QoL and mental health, increased pain catastrophizing and anxiety
Observational data: associations, not effects.
Original publication
Pain, Quality of Life, and Mental Health in Adults with X-linked Hypophosphatemia: A Cross-sectional Study. J Clin Endocrinol Metab. Published 19 February 2025. doi:10.
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