Overweight and macrovascular complications in type 1 diabetes: A nationwide registry study (J‑DREAMS)
Main finding · CAD prevalenceResult — go to the resultAdjusted odds ratio 2.41 95 % CI 1.15–5.06Authors' conclusion
In Japanese adults with type 1 diabetes, overweight is independently associated with CAD but shows no significant associations with CVD or PAD;overweight in early adulthood tracks with adverse cardiometabolic profiles. Early, sustained weight management with glycemic control may reduce macrovascular risk.
Study context
- Population
- Japanese adults with T1D in the J-DREAMS registry (2016–2023)
- Participants
- 2,181 adults
- Exposure
- Overweight vs non-overweight
- Outcome
- Prevalence of coronary artery disease (CAD), cerebrovascular disease (CVD) and peripheral artery disease (PAD)
Methodological detailsnationwide, cross-sectional analysis
- Nationwide
- Cross-sectional analysis
Main finding
CAD prevalence
Adjusted odds ratio
2.41
95 % CI 1.15–5.06
By group
Overweightvs Non-overweight
aOR 2.41 (95 % CI 1.15–5.06)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Microvascular complications and comorbidities
- Overweight linked to more neuropathy, nephropathy, hypertension and dyslipidemia
Overweight at age 20 (n = 124) vs not (n = 944), among 1,068 with BMI at age 20
- Prior overweight at age 20 associated with higher current BMI and HbA1c and more peripheral artery disease (PAD), retinopathy, nephropathy, hypertension and HF
Original publication
Overweight and macrovascular complications in type 1 diabetes: A nationwide registry study (J‑DREAMS). Diabetes Res Clin Pract. Published 20 October 2025. doi:10.
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